Objective: To prepare baicalin liposome and investigate effect of in vitro apoptosis on liver cancer HepG2. Method: With encapsulation efficiency as main index

investigated preparation method and prescription form

optimum prescription technology were selected

studied form

stability and other physical and chemical properties

and effect of apoptosis on liver cancer HepG2 were investigated. Result: Liposome was oval under electron microscope

it was stable under refrigerated conditions

prepared by film encapsulation efficiency was (34.62 ± 0.89)%. Cell apoptosis rate was positive correlation with dosage and action time of preparation. Conclusion: This method was simple and feasible. This preparation had significantly in vitro inhibition on HepG2 cell.