Objective:To review the application of placenta in the treatment of with chronic refractory ulcer and to investigate the form of placenta used as medicines. Method:The relevant articles were searched for in China Journal Full-text Database (CJFD) in China National Knowledge Infrastructure (CNKI) network with the key words ‘placenta’

one hundred and thirty-eight articles were retrieved

with the key words ‘placenta and ulcer’ 1 article was retrieved. This paper describes the records of the ancient literature of the Placenta

explores the main components of placenta and the role of these components in treatment of chronic ulcers. Then

the clinical application of the placenta was studied. Finally

we investigate the form of placenta used as medicines. Result: Placenta plays an important role in the treatment of patients with refractory chronic ulcer. However

placenta used as medicines mostly was internal medicine

hardly used for external. Conclusion: Placenta used as internal medicine can supplement yin and yang

qi and blood. Placenta used for external can accelerate the healing of the wound.