Objective: To optimize preparation process of β-asarone cataplasm. Method: Orthogonal design test was employed to optimize matrix proportion and molding technology of β-asarone cataplasma with glossiness

adhesiveness

matrix residue

skin following and repeatedly exposing as indexes. Result: Optimum matrix proportion of carbomer-pressure sensitive adhesive-polyvinyl alcohol-sodium carboxymethy cellulose-gelatinum-citric acid-sodium citrate-glycerol-propylene glycol was 0.3:1:0.05:0.35:0.1:0.12:0.18: 3.5:3.5. Optimized molding technology were that stiring speed was 500 r·min-1

refining temperature was 45 ℃

refining time was 15 min

the content of of β-asarone was 8.7%. Conclusion: Optimized β-asarone cataplasm had a good adhesive power

excipients and glossiness

drug loading was large and no skin left.This preparation had a certain advantages and wide application prospects for treatment of stroke.