To carry out the literature arrangement and analysis about chemical instability of Tween-80 (polysorbate 80) and its compatibility and preparation. We took Tween-80 as a keyword

indexed systematically some databases of PubMed

Wiley Online Library

Science

ScienceDirect

Highwire

Biomed Central

and CNKI up to now

picked up 35 related references

and summarized according to the kinds of organic reaction. The organic reactions

giving expression to the unstable property of Tween-80

included hydrolysis

complexation

autoxidation

polymerization

photodegeneration

and an undefined reaction. When the injection containing Tween-80 is researched and developed

the probalble interaction of Tween-80 and medicinal molecule and the procedure and condition of all links from raw material choice to clinical usage should be considered thoroughly. We should prevent the appearance of any unstable phenomena and prepare safe and stable injection preparation containing Tween-80.