Objective: To establish the chromatographic fingerprint analysis for the quality control of the content of flavonoids in Sanjie Zhentong capsules. Method: Under the operation of ultrasonic extraction

the flavonoids from Sanjie Zhentong capsules were extracted in the 50% methanol. With Waters Symmetry@ C18(4.6 mm×250 mm

5 μm)column

and gradient elution was performed by mobile phase containing acetonitrile and water. The flow rate was 1.0 mL·min-1 and the detection wave length was at 203 nm. The temperature of column was maintained at 30 ℃. And data were analyzed by ‘Similarity evaluation software for chromatographic Fingerprint of traditional Chinese medicine' software to compare the quanlity of 11 batches of capsules samples. Result: Fifty common peaks were selected in chromatography

and all the common peaks were separated effectively. Conclusion: The accuracy

repeatability

and stability of this method were satisfied.The method developed can be used to evaluate the quality of Sanjie Zhentong capsules synthetically.