加减沙参麦冬汤联合化疗治疗Ⅲ,Ⅳ期 非小细胞肺癌

肖寒; 方乃青; 申小苏

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加减沙参麦冬汤联合化疗治疗Ⅲ,Ⅳ期非小细胞肺癌

更新时间：2024-01-04

- 加减沙参麦冬汤联合化疗治疗Ⅲ,Ⅳ期非小细胞肺癌
- Clinical Observation in Patient with Non-small Cell Lung Cancer Treated with Jiajian Shashen Maidong Decoction Integrated with Chemotherapy
- 中国实验方剂学杂志 2011年17卷第24期页码：203-207
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- 纸质出版日期：2011
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肖寒, 方乃青, 申小苏. 加减沙参麦冬汤联合化疗治疗Ⅲ,Ⅳ期非小细胞肺癌[J]. 中国实验方剂学杂志, 2011,17(24):203-207.

XIAO Han, FANG Nai-qing, SHEN Xiao-su. Clinical Observation in Patient with Non-small Cell Lung Cancer Treated with Jiajian Shashen Maidong Decoction Integrated with Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 203-207.
肖寒, 方乃青, 申小苏. 加减沙参麦冬汤联合化疗治疗Ⅲ,Ⅳ期非小细胞肺癌[J]. 中国实验方剂学杂志, 2011,17(24):203-207. DOI：

XIAO Han, FANG Nai-qing, SHEN Xiao-su. Clinical Observation in Patient with Non-small Cell Lung Cancer Treated with Jiajian Shashen Maidong Decoction Integrated with Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 203-207. DOI：

摘要

目的 :观察加减沙参麦冬汤联合TP(紫杉醇+顺铂)方案对Ⅲ

Ⅳ期非小细胞肺癌化疗患者免疫功能以及生存质量的影响。方法 :43例肺癌患者随机分为化疗组和中药加化疗组

化疗组患者用TP方案化疗

中药加化疗组在该方案化疗的基础上口服加减沙参麦冬汤治疗。在化疗前以及两周期化疗后检测外周血T淋巴细胞以及NK细胞免疫功能

并进行EORTC QLQ-C43量表评分。结果 :Ⅲ~Ⅳ期、有淋巴结转移的晚期肺癌患者免疫功能低于分期早、无淋巴结转移患者。在单纯化疗组中

2个周期化疗后CD3+

CD4+

CD4+/CD8+水平明显下降

而中药加化疗组

2个周期化疗后CD3+

CD4+

CD4+/CD8+水平较化疗前有所增加。对照组经过两疗程治疗后

大部分功能领域

如躯体、社会、角色、情绪、认知功能等评分呈显著下降趋势

症状领域评分不同程度上升

提示生存质量状况趋于恶化。而中药加化疗组患者

其症状子量表及肺癌特异子量表得分降低

表明症状减轻

生理状况好转

并且躯体、社会、角色、情绪、认知功能状况以及总健康状况明显提高

显示患者整体生存质量的改善。中药加化疗组能抑制白细胞减少

减轻恶心呕吐等化疗副反应。结论: 加减沙参麦冬汤联合化疗能改善化疗患者免疫功能

提高生存质量

减少恶心、呕吐等化疗副作用。

Abstract

Objective : To study the effects of the immunologic function and quality of life in the patient with lung cancer treated with Jiajian Shashen Maidong decoction integrated with paclitaxel and cisplatin. Method : Forty-three cases with lung cancer patients were randomly divided into a chemotherapy group and a chemotherapy plus Chinese medicine group. Patients in chemotherapy group were treated with paclitaxel and cisplatin. The chemotherapy plus Chinese medicine group patients were given paclitaxel and cisplatin and Jiajian Shashen Maidong decoction. Immunologic indexes and EORTC QLQ-C43 scale were investigated in all groups. Result : The immunologic function in the patients of Ⅲ-Ⅳstage and lympf node metastases was lower than the patients of early stage and non-lympf node metastases. In chemotherapy group

levels of CD3+

CD4+

CD4+/CD8+were decreased after 2 cycle chemotherapy.In chemotherapy plus Chinese medicine group

levels of CD3+

CD4+

CD4+/CD8+ were increased. Improvement of KPS

leucocyte and quality of life

reducing nausea and vomitting in chemotherapy plus Chinese medicine group after treatment was significantly superior to that in chemotherapy group. The score in the most domains of EORTC QLQ - C43 QOL was decreased in functional scales but increased in symptom scales

which means the quality of life was deteriorated. While in treatment group

the score in symptom scales and EORTC QLQ-LC43 was decreased

Which means the symptom was reduced. The scores of physical functioning

social functioning

role functioning

emotional functioning

cognitive functioning and globle health were increased which shows that patients' QOL was improved. The effective rate of traditional Chinese medicine (TCM) symptom in treatment group was higher than that in control group

there was a ignificant difference between two groups In the treatment group the score of TCM symptom was decreased after two cycles chemotherapy

but in the control group the score was of no change. Conclusion : Jiajian Shashen Maidong decoction has functions of increasing immunologic function and quality of life

and reducing side effect of chemotherapy. The treatment scheme of chemotherapy combined with Chinese medicine may be important.

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