Objective: To investigate effects of total polyphenols extracted from Toona sinensis Roem on acute inflammation in injury induced by myocardial ischemia-reperfusion in rats. Method: Fifty SD rats were randomly divided into 5 groups: sham operation group

model group and total polyphenols extracted from T. sinensis groups in 3 doses. Myocardial ischemia/reperfusion injury in rats was induced by legating the left coronary artery (LAD) 30 min followed by a 120 min reperfusion

while rats in sham group were sutured only. Ligature success was indicated by elevation of segment

yet reperfusion success was indicated through gradual resolution of T wave with ST segment

and appearance of infract Q wave. After reperfusion

blood from abdominal aorta was collected

and serum were prepared. Then content of IL-6 and TNF-α in serum were detected. Finally

10 mg myocardium tissue was cut from left ventricle ischemic area

and expression level of NF-κB p65 mRNA was tested. The rest myocardium tissues were prepared for pathological sections. Then the morphological changes in left ventricle ischemic area was observed through optical Microscope. Result: Content of IL-6 and TNF-α in model group serum were (638.88±188.94)

(216.23±58.67) ng·L-1 respectively. Compared with rats in model group

after administrated with polyphenols extracted from T. sinensis Roem

the content of IL-6 and TNF-α in serum was declined. NF-κB p65/β-actin in left ventricle ischemic area myocardium tissue of model group was 0.61±0.05

while myocardium tissue NF-κB p65/β-actin in total polyphenols extracted from T. sinensis groups were decreased significantly. Compared with model group

the morphological injury of cardiomyocytes in total polyphenols extracted from T. sinensis groups were alleviated significantly. Conclusion: Total polyphenols extracted from T. sinensis can play an intervention role on acute inflammation during myocardial ischemia-reperfusion in rats.