Objective :To investigate correlation between syndromes differentiation typing(SDT) with leptin and insulin resistance in chronic hepatitis C. Method : Screened One handre and sirty cases of chronic hepatitis C patients and Smmarized its syndromes differentiation typing. Serum leptin levels

fasting blood glucose and insulin levels were measured

fifty cases in healthy control group and make the regression analysis with the above indicators and SDT. Result: The type of shi-re stasis is highest proportion in chronic hepatitis C

followed by liver stagnation and spleen deficiency

blood stasis

deficiency in liver-kidney

deficiency in spleen and kidney

compared with the healthy control group

in addition to spleen-kidney deficiency

The remaining syndromes are obvious hyperleptinemia and insulin resistance

followed by spleen-kidney deficiency

liver stagnation and spleen deficiency

shi-re stasisl blood stasis

in which shi-re stasis and blood stasis type is easier to steatosis. Conclusion: The type of shi-re stasis is the main syndromes of chronic hepatitis C

hyperleptinemia and insulin resistance is the indicators in SDT of chronic hepatitis C.