Objective: To define effect of chemical composition under decocting together with different group condition. Method: Different compatibility group was adopted

the content of target composition was determined after decocted

compared between two groups

and defined whether to decoct. Result: ①Manis pentadactyla and Chinemys reevesii decocted with drug containing volatile oil

it would not extract volatile oil in this way;②M. pentadactyla and C. reevesii could reduce decocting ratio of alkaloids;③Rheum palmatum could decrease decocting ratio of gentiopicroside;④drugs containing alkaloids could decrease decocting ratio of anthraquinone from R. palmatum. Conclusion: Animal drugs could affect extraction ratio of volatile oil;drugs containing gentiopicroside alkaloids could not decoct with R. palmatum.