Objective: To investigate the effect of Bugu Fangshu decoction on osteoprotegerin(OPG) in osteoporosis rats. Method: The experimental animals were divided into 4 groups

and the model was made by administration of retinoic acid. The osteoporosis rats were treated by middle-dose Bugu Fangshu decoction(MDB group

20 g·kg-1)

high-dose Bugu Fangshu decoction(HDB group 40 g·kg-1). Expression of OPG in bone tissues and morphological changes of bone tissue were observed. Result: Retinoic acid ig 2 weeks

the model control group rats significantly sparse trabecular bone

trabecular bone area percentage of (22.52±3.15)%. spectral area of OPG bone density (IA) value of 0.29±0.15

significantly lower than the normal group (P<0.01)

shows that successful model. After treated by Bugu Fangshu

the percentage of trabecular bone area of MDB group and HDB group is (36.41±1.40)% and (37.58±1.40)%

significantly higher than the control group (P<0.01). The OPG IA of bone is 2.41±1.40

3.07±0.40

was significantly increased (P<0.01)

significant improvement in pathological changes in bone tissue. Conclusion: Bugu Fangshu decoction could increase significantly the expression of OPG and improve pathological changes of osteoporosis obviously.