Objective: Toinvestigate the protective effect of curcumin on oxidative stress injury induced by myocardial ischemia reperfusion(MIR) in rats in cardz pumonary by pass(CPB). Method: Sixty healthy SD rats were randomized in to six groups:shamgroup

MIR group

PEG group

MIR+high dose curcumin treatment group

MIR+ middle dose curcum in treatmen tgroup

MIR+low dose curcum in treatment group.My ocardial IR was carried out by ligation of left anterior descending coronary artery for 30 min followed by reperfusion for 60 min.Dif-ferent dosages of curcumin were administered 30 min before the ligation.Blood was collected at the end of reperfusion for detecting changes of aspartate aminotransferase(AST)

lactate dehydrogenase(LDH)

lactate dehydrogenase1(LDH1)

superoxide dismutase(SOD)

and malondialdehyde(MDA).The myocardial infarct size was also estimated. Result: Curcumin pretreating dose-depend-ently decreased the contents of AST

LDH

LDH1 and MDA

and the myocardial infarct size

and increased the activity of SOD with dose-dependent manner. Conclusion: Curcum in exerts protective effects on myocardial is chemia reperfusion injury.