ZOU De-jun, ZHANG Hong, GAN Yu, et al. Effect of Guanmaitong Capsules on Experimental Thrombogenesis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 229-230.
ZOU De-jun, ZHANG Hong, GAN Yu, et al. Effect of Guanmaitong Capsules on Experimental Thrombogenesis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 229-230.DOI:
Objective: To study the Guanmaitong capsules(GMT) on the experimental thrombosis. Method: Sixty SPF Wistar rats were randomly divided into six groups:the normal control group
GMT groups(0.67
1.34
2.68 g·kg-1
ig)
Guanxindanshen capsules group(0.24 g·kg-1
ig)and indobufen tablets group(0.04 g·kg-1
ig).The experimental thrombosis model was induced by electric stimulation.Rats need to take medicine seven days.After thirty minutes of the last one
we should strip the carotid artery and ligate the two sides of thrombus. Weighting the weight of thrombus and statistics the average blocking rate would be done. Result: Compared with the noamal control group(50.99%)and(0.002 6 g)
the average thromboembolism rate of GMT(40.25%
39.05%
37.11%) and the weight of thrombus( 0.001 9
0.001 7
0.001 5 g)could significantly decrease(P<0.05
P<0.05
P<0.01). meanwhile existing the quantity-efficiency relations. Conclusion: The results showed that GMT could decrease the weight of the thrombus.