Objective: To determine optimum preparation technology of annonaceous acetogenin dripping pill(AADP) by researching various factors on it. Method: Shape of dripping pill

hardness

dissolution time and pill weight as parameters to select formulation technology and dripping conditions of pill. The content of annonaceous total acetogenin was determined by UV spectrophotometry. Result: Optimum technology was: methyl-silicon oil as refrigerant

proportion of PEG4000-PEG6000 was 4 ∶1

annonaceous acetogenin to matrix was 1 ∶4

processing temperature was at 70 ℃

and cooling temperature was 5-15 ℃

dripping distance was 2 cm and ID/OD of emitter was 2/2.5 mm; The content of annonaceous total acetogenin was 2.53

2.54

2.66 mg. Conclusion: This process was simple

feasible and reproducible; Ultraviolet spectrophotometry method was simple

accurate and could be used to control quality of this dripping pill.