无症状HIV感染者治疗前后血清新喋呤检测的临床意义

王丹妮; 姜枫; 顾侦芳; 李政伟

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无症状HIV感染者治疗前后血清新喋呤检测的临床意义

更新时间：2024-01-04

- 无症状HIV感染者治疗前后血清新喋呤检测的临床意义
- Clinical Significance on Change of Serum Neopterin Level Before and After Treatment in Patients with Asymptomatic HIV Carriers
- 中国实验方剂学杂志 2012年18卷第2期页码：225-227
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- 作者简介：
- 基金信息：
  
  科技部国际合作项目(2007DFB31610);国家自然科学基金项目(30901906,81102575);中国博士后科学基金项目(20080440743);国家"十一五"科技重大专项(2008ZX10005-002)
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- 纸质出版日期：2012
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王丹妮, 姜枫, 顾侦芳, 等. 无症状HIV感染者治疗前后血清新喋呤检测的临床意义[J]. 中国实验方剂学杂志, 2012,18(2):225-227.

WANG Dan-ni, JIANG Feng, GU Zhen-fang, et al. Clinical Significance on Change of Serum Neopterin Level Before and After Treatment in Patients with Asymptomatic HIV Carriers[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 225-227.
王丹妮, 姜枫, 顾侦芳, 等. 无症状HIV感染者治疗前后血清新喋呤检测的临床意义[J]. 中国实验方剂学杂志, 2012,18(2):225-227. DOI：

WANG Dan-ni, JIANG Feng, GU Zhen-fang, et al. Clinical Significance on Change of Serum Neopterin Level Before and After Treatment in Patients with Asymptomatic HIV Carriers[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 225-227. DOI：

摘要

目的: 探讨无症状人类免疫缺陷病毒(HIV)感染者治疗前后血清新喋呤(NPI)水平的变化及意义。方法: 应用酶联免疫吸附法对32例无症状HIV感染者进行了血清NPI水平测定

并与22名健康体检者作比较。结果: 32例无症状HIV感染者治疗前血清NPI浓度显著高于健康对照组(P<0.05)。无症状HIV感染者血清NPI经中药扶正排毒片1.85 g

3次/d相当于生药19.8 g

3次/d

温开水冲服

治疗6个月后与治疗前相比有明显下降

统计学有显著性差异(P<0.05)

但仍高于健康对照组;治疗后与健康对照组相比有显著性差异(P<0.05)。结论: 血清NPI水平升高代表的异常免疫激活是无症状HIV感染者的病理因素之一

扶正排毒片可以降低无症状HIV感染者血清NPI水平

是其疗效的可能机制之一。

Abstract

Objective: To explore the change of serum neopterin(NPI) levels before and after treatment in patients with asymptomatic human immunodefilienly virus (HIV) carriers. Method: ELISA method was used to determine serum NPI levels of 32 patients with asymptomatic HIV infection and 22 healthy subjects were entered control group. Result: Before treatment there was statistical significance in NPI compared with the healthy control group (P<0.05)

after 6 months of treatment by Fuzheng Paidu tablet

there was statistical significance in the change of NPI (P<0.05)

self-comparison before and after treatment was statistically significant (P<0.05). Conclusion: The abnormal immune activation induced by increased serum levels of NPI may be one of the pathological factors in patients asymptomatic HIV infection

Fuzheng Paidu table can reduce the level of serum NPI in asymptomatic HIV carriers

which may be one of the possible mechanisms.

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