Objective: To explore the molecular immunologe mechanisms of Zhenwu Tang for protecting kidney from injury. Method: Rats were randomly divided into 5 groups

in addition to the normal group

the remaining rats were operated for unilateral ureteral obstruction model(UUO)

and then losartan (20 mg ·kg-1)

Zhenwu Tang low and high dose (crude drug 2.1

9.8 g ·kg-1) were administered

respectively. Model group and control group were given saline. Serum were collected at day 29 after UUO modeling

and the cytokines including monocyte chemoattractant protein-1(MCP-1)

plasminogen activator inhibitor-1(PAI-1)

tumor necrosis factor-α(TNF-α)

interleukin-1β(IL-1β)

IL-6 and adiponectin: were detected by multiple cytokine luminex detection. Result: The serum content of MCP-1

PAI-1

and IL-6 in UUO model was significantly higher compared with normal rats. The serum content of Adiponetin TNF-α

and IL-1β was no significantchange. Zhenwu Tang can significantly reduce elevated blood PAI-1

IL-6

MCP-1 levels. Conclusion: The molecular mechanism of Zhenwu Tang in remission of renal interstitial firosis may be related to reduce serum MCP-1

PAI-1 and IL-6 levels.