Objective: To observe the effects of aqueous extract from Potentilla discolor Bunge (APB) on blood glucose and lipids level in type 2 diabetic rat model. Method: Three week-old Wistar male rats were divided randomly into two groups according to random data table: control group with rat standard diet and model group with high-fat diet (HFD)for 16 weeks in order to induce insulin resistance and type 2 diabetic model

the HFD group was intraperitonealy given small dose STZ. Then

the model rats were divided into 4 groups: model group

positive control group (pioglitazone 4.05 mg·kg-1)

high-dose group (400 mg·kg-1) and low dose group (200 mg·kg-1) of APB aqueous extract

7 rats in each group. The control group and model group were fed with distilled water at 10 mL·kg-1. After 4 weeks of drug intervention

the fasting blood glucose (FBG)

serum triglyceride (TG)

serum total cholesterol (TC)

serum free fatty acid (FFA)

serum low-density lipoprotein (LDL-C) and serum high density lipoprotein (HDL-C) were examined. Result: Both the aqueous extract and the pioglitazone group significantly decreased FBG

TG

TC

LDL and FFA level

and increased the HDL level(P<0.05). Conclusion: Aqueous extract of P. discolor may offer an alternate treatment for diabetes by regulating fasting blood glucose and serum lipids levels in type 2 diabetic insulin resistance rats.