正交设计优选四神结肠片提取工艺

管咏梅; 陈振华; 熊英; 程磊; 王森; 朱卫丰; 杨明; 刘红宁

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正交设计优选四神结肠片提取工艺

更新时间：2024-01-04

- 正交设计优选四神结肠片提取工艺
- Optimization of Extraction Technology for Sishen Colon Targeting Tablets by Orthogonal Design Test
- 中国实验方剂学杂志 2012年18卷第6期页码：7-9
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- 作者简介：
- 基金信息：
  
  重大新药创制项目(2009ZX09310-005)
- DOI：
  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
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管咏梅, 陈振华, 熊英, 等. 正交设计优选四神结肠片提取工艺[J]. 中国实验方剂学杂志, 2012,18(6):7-9.

GUAN Yong-mei, CHEN Zhen-hua, Xiong Ying, et al. Optimization of Extraction Technology for Sishen Colon Targeting Tablets by Orthogonal Design Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 7-9.
管咏梅, 陈振华, 熊英, 等. 正交设计优选四神结肠片提取工艺[J]. 中国实验方剂学杂志, 2012,18(6):7-9. DOI：

GUAN Yong-mei, CHEN Zhen-hua, Xiong Ying, et al. Optimization of Extraction Technology for Sishen Colon Targeting Tablets by Orthogonal Design Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 7-9. DOI：

摘要

目的: 采用正交试验设计优选四神结肠靶向片的提取工艺。方法: 以乙醇体积分数、溶媒用量、提取次数及提取时间为考察因素

以补骨脂素、异补骨脂素、吴茱萸碱、吴茱萸次碱的提取率及出膏率为考察指标

采用L9(34)正交试验优选四神结肠靶向片的HPLC含量测定及提取工艺。结果: 最佳提取工艺为加8倍量60%乙醇回流提取3次

每次提取1.5 h。结论: 优选提取工艺合理

提取效率高

适用于工业生产。

Abstract

Objective: To optimize extraction technology for Sishen colon targeting tablets by orthogonal test design. Method: L9(34) orthogonal test was used for optimizing content determination extraction technology for Sishen colon targeting tablets with the concentration of ethanol

the amount of solvent

extraction times and extraction time as investigation factors

extraction rate and extract yield of psoralen

isopsoralen

evodiamine

rutaecarpine was taken as indexes. Result: Optimum extraction technology was as follows: reflux extracted 3 times with 8 times the amount of 60%ethanol for 1.5 h each time. Conclusion: Optimized extraction technology was rational with high extraction efficiency

it was suitable for industrial production.

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