Objective: To compare the 6 lignans components content such as schizandrol A in different granularity of Schisandra chinensis in order to confine clinical best effective utilization rate. Method: Through the high-performance liquid chromatography (HPLC) to determinate 6 lignans components content such as schizandrol A in different granularity of Schisandra chinensis after water decoction to contrast the effective component utilization rate. Result: The crushed group of Schisandra chinensis was obviously higher than the not crushed group about the 6 lignans components content such as schizandrol A. The contents of 6 compounds in 50

65

80

100 mesh of crushed Schisandra chinensis were increased with the particle size reduction

but there was a little differences. Conclusion: The crushed group is well than the not crushed group

the fine particle size increased the cost of work

So when clinical use in Fructus Schisandrae should advisable of using the 50 mesh thick powder.