Objective: To investigate influence of different additions on stability of Calamine lotion

and then obtained optimum prescription of Calamine lotion. Method: Optimum additions were investigated with influence of CMC-Na

gummi tragacanthae

Tween-80

AlCl3 and sodium citrate on stability of Calamine lotion by sedimentation volume ratio experiment and redistributed experiment

additions was optimized by orthogonal experiment. Result: The best suspension agent was CMC-Na

Tween 80 could improve stability of suspension. Optimum prescription was:Calamine lotion 7.5 g

ZnO 2.5 g

Glycerin 2.5 g

CMC-Na 0.5 g

Tween-80 0.125 g

AlCl3 0.05 g. Conclusion: Prescription of Calamine lotion after optimization could improve stability of formulation greatly

and it was simple

feasible

it could be used in industrialized production.