Objective: To observe clinical efficiency of Shugan Huoxue Mingmu decocotion combined with methylprednisolone pulse therapy. on acute optic neuritis(AON). Method: Fifty patients (54 eyes) with AON were randomly divided into treatment group and control group. All patients were given methylprednisol impacting and the general adjuvant therapy. The treatment group was given Shugan Huoxue Mingmu decocotion. The treatment course was 1 month

and the clinical observation lasted two courses. Before and after treatment

visual acuity

fundus

visual field and other changes were observed. Result: The total effective rate was 100% in the treatment group and 92.0% in the control group

and there was a statistically significant difference(P<0.05).The changes in visual acuity

fundus

visual field of the treatment group were improved compared with control group. Conclusion: Shugan Huoxue Mingmu decocotion combined with methylprednisolone can significantly improve clinical symptoms of AON patients and increase visual acuity

reduce the average threshold sensitivity of vision

the optic nerve edema and promote the absorption of retinal hemorrhage.