HPLC测定11种中药口服液中6种防腐剂的含量

孙蒙; 闫小玉; 毕开顺; 陈晓辉

您当前的位置：

首页 >

文章列表页 >

HPLC测定11种中药口服液中6种防腐剂的含量

更新时间：2024-01-04

- HPLC测定11种中药口服液中6种防腐剂的含量
- Simultaneous Determination of Preservatives in Traditional Chinese Oral Liquid Preparation by HPLC
- 中国实验方剂学杂志 2012年18卷第3期页码：76-79
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
移动端阅览
孙蒙, 闫小玉, 毕开顺, 等. HPLC测定11种中药口服液中6种防腐剂的含量[J]. 中国实验方剂学杂志, 2012,18(3):76-79.

SUN Meng, YAN Xiao-yu, BI Kai-shun, et al. Simultaneous Determination of Preservatives in Traditional Chinese Oral Liquid Preparation by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 76-79.
孙蒙, 闫小玉, 毕开顺, 等. HPLC测定11种中药口服液中6种防腐剂的含量[J]. 中国实验方剂学杂志, 2012,18(3):76-79. DOI：

SUN Meng, YAN Xiao-yu, BI Kai-shun, et al. Simultaneous Determination of Preservatives in Traditional Chinese Oral Liquid Preparation by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 76-79. DOI：

摘要

目的: 建立HPLC同时测定中药口服液体制剂中防腐剂含量的方法。方法: Kromasil C18色谱柱(4.6 mm×250 mm

5 μm)

流动相乙腈-0.02 mol ·L-1乙酸铵溶液梯度洗脱

流速1.0 mL ·min-1

检测波长240 nm

柱温30 ℃。结果: 苯甲酸、山梨酸、对羟基苯甲酸酯类在1.0~181.1 mg ·L-1线性关系良好(r>0.999);平均回收率95.5%~100.8%(RSD 0.7%~1.5%)。结论: 方法简单、可靠

精确

可用于中药口服液体制剂中防腐剂含量的测定。

Abstract

Objective: To establish a HPLC method for simultaneous determination of preservatives in traditional chinese oral liquid preparation. Method: The chromatographic separation was achieved on a Kromasil C18(4.6 mm×150 mm

5 μm) column with acetonitrile-0.02 mol ·L-1 ammonium acetate solution as mobile phase(gradient elution).The flow rate was 1.0 mL ·min-1

the detective wavelength was set at 240 nm

and the column temperature was maintained at 30 ℃. Result: Benzoic acid

sorbic acid and parahydroxybenzoate ester have a good resolution and linear correlation in certain range

respectively (r>0.999). The average recoverieswere 95.5%-100.8% (RSD 1.5%-1.8%). Conclusions: The method is simple

reliable and accurate for determination of preservatives in traditional chinese oral liquid preparation.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

赤芍野生品与栽培品4种化学成分含量的比较

HPLC测定复方土荆皮酊中3种成分的含量

HPLC测定丹膝颗粒中丹酚酸B的含量

近红外漫反射光谱法在青翘含量测定中的应用