Objective: To investigate the effects of Tangpingjian(TPJ) on insulin resistance(IR) and serum Adiponectin (Adip)

leptin

tumor necrosis factor alpha(TNF-α) in type 2 diabetic(T2DM) rats. Method: The type 2 diabetic rats model was established by the injection of small-dose streptozotocin (STZ 30 mg·kg-1) combined with high-energy feeding. The rats were randomly assigned to the model group

TPJ high-dose

TPJ small dose group and normal control groups. Rats in TPJ high-dose group were performed intragastric administration of 14.4 g·kg-1·d-1 crude drug of Tangpingjian

and rats in TPJ small dose group were administrated with 7.2 g·kg-1·d-1 crude drug of Tangpingjian

the other two groups were administrated with distilled water by equal volume. All four groups had been treated for four weeks. Fasting blood-glucose (FBG)

Fasting insulin(FINS)

TNF-α

Adip and Leptin of rats were measured after four weeps. Calculation of insulin sensitivity index was carried out(IAI). Result: TPJ could decrease FBG

FINS

leptin and TNF-α remarkably

and improve insulin sensitivity index and Adip activity obviously in experimental rats. It has remarkable difference compared with model group (P<0.01

P<0.05). Conclusion: TPJ can improve T2DM rat inflammatory response

reduce hyperinsulinemia

increase the insulin sensitivity

and improve insulin resistance.