Objective: To investigate the protective effects of Ligustrazine combined with puerarin on the changes of neurological deficits. Method: Rats were randomized into sham-operation group

model group

Ligustrazine-puerarin group(ligustrazine 50 mg·kg-1-puerarin 50 mg·kg-1)and nimodipine group(0.5 mg·kg-1). The model was established by 4 vessel occlusion method. The changes in nerve function and brain morphology were evaluated. Result: After ischemia reperfusion

the model group neurologic deficit and morphological changes were higher than that in the sham-operation group significantly (P<0.01).Neuronal damage and inflammatory reactions could be found in the model group(the sections stained with Nissle staining). In Ligustrazine-puerarin group and nimodipine group

the neurologic deficit scores and morphological changes were lower than that in the model group (P<0.05

P <0.01). Conclusion: Ligustrazine-puerarin can prevent and alleviate the ischemia and reperfusion injury to some degree.