Objective: To analyze the active ingredient distribution in Salvia different parts. Method: An HPLC was applied using dual wavelength detection and analytical column of Shim-pack VP-ODS C18 (4.6 mm×150 mm

5 μm). The mobile phase was consisted of acetonitrile-0.02% phosphoric acid solution by gradient elution. The flow rate was 1.0 mL·min-1 with the detection wavelength at 270 nm and 280 nm.The active ingredients were measured by HPLC in Salvia rough bark part

the part without the rough bark and the original medicinal part. Result: The distribution of Salvia active ingredients is different

of which cryptotanshinone

tanshinone ⅡA

protocatechuic aldehyde

caffeic acid mainly were found in the rough bark part and danshensu and Sal B were mainly distributed in the part without the rough bark. In cultivation Salvia

the content of cryptotanshinone

tanshinone ⅡA

protocatechuic aldehyde

caffeic acid

danshensu and Sal B in the rough bark part were 1 933.6%

1 554.7%

700%

268.4%

56.6% and 61.1% compared with that in the part without the rough bark respectively. In wild Salvia

the content of cryptotanshinone

tanshinone ⅡA

protocatechuic aldehyde

caffeic acid

danshensu and Sal B in the rough bark part were 1 393.0%

1 822.0%

235.7%

150%

62.8% and 90.4% compared with that in the part without the rough bark respectively. The content of Sal B

cryptotanshinone

tanshinone ⅡA in cultivation Salvia was high. Conclusion: The differences in composition in different parts of Salvia confirmed the traditional classification scientific

and can guide our rational use of Salvia resources.