Objective: To study on effects of different enhancers and their combinations on transdermal permeability of curcumine

and to evaluate feasibility of transdermal delivery. Method: Multiple penetration enhancers were chosen

The content of drug in receiving liquid was determined by in vitro diffusion cell method and UV spectrophotometry

and investigated its effects on in vitro transdermal permeability of curcumine. Result: Penetration enhancers

such as Beta cyclodextrins (β-CD)

Hydroxypropyl beta cyclodextrins (HP-β-CD)

peppermint oil

camphor

borneol

ethanol

and their combinations all had peneration enhancing effect except for Azone

HP-β-CD had the most. Conclusion: Satisfactory penetration of curcumine through rat skin could be obtained by choosing proper enhancers.