Objective: Analgesic

anti-inflammatory actions and irritation

hypersensitiveness were observed to evaluate the pharmacodynamics and safety of Yulian cataplasm

and to provide the experimental basis for clinical applications of the cataplasm. Method: The experiment animals were randomly divided into Yulian cataplasm high

middle and low dose groups(12

6

3 g·kg-1).Carrageenan was used to induce rat paw edema. The mice inflammatory and algetic models were established by chemical irritation. Somatic writhing; foot swelling and capillary permeability were observed. The intact and damaged skins of rabbits were used to carry out irritation trial

and the hypersensitivity trial was conducted in guinea pigs. Result: Both middle and low dose groups of Yulian cataplasm could reduce rat paw swelling

middle dose group lasted longer duration of action. High and middle dose groups could decrease capillary permeability. All the three dose groups could reduce the writhing

and compared with excipient group (P<0.05

P<0.01). Irritation and hypersensitivity were not found. Conclusion: Yulian cataplasm could obviously exert both analgesic and anti-inflammatory actions

and no irritation and hypersensitivity were found.