Objective :To observe the affection of angelica astragalus ethanol-extraction (AAE) on experimental itchy skin model. Method : The incubation period and the times of itch in mice pruritus model induced by dextran

and the itching threshold in guinea pig induced by phosphoric acid histamine were researched. The inflammatory edema of ear induced by xylol in mice and the increase in mice’s capillary permeability by histamine phosphate were also investigated. The effects of AAE (5.0

10.0

20.0 g ·kg-1

ig. for 7 d in mice; 8.6

7.2

14.4 g ·kg-1 ig

for 7 d in guinea pigs) on all of this models were investigated comprehensively. Result : All dosages of AAE could decrease the times of itch and prolong the incubation period in mices

high and middle doses of AAE obviously inhibit the local itching of guinea pigs and decrease the ear swelling degree or the area of urticaria and the Evans blue absorbance also. Conclusion : There would be antipruritic

antipruritic and anti inflammatory effect of AAE. It has therapeutic effect on experimental pruritus.