Objective: To optimize matrix formulation process of Xiaoguzeng patch. Method: L18(37) orthogonal test was designed

NP700

glycerol

EDTA

PVPPXL-10

aluminum glycinate

PVPK90 and liquid medicine as factor

dosage of these as lever. Adhesion force

membrane residues and composite indicator were considered as index. Result: The greatest impact on adhesion force was NP700

followed by glycerol

and they had a significant effect on adhesion force. The greatest impact on membrane residues and composite indicator was PVPPXL-10.Optimum matrix formulation of Xiaoguzeng patch was NP700-glycerol-EDTA-PVPPXL-10-aluminum glycinate-PVPK90-liquid medicine as 6 ∶30 ∶0.025 ∶1 ∶0.05 ∶1 ∶20. Conclusion: This process was simple and easy to industrialization.Prepared by optimum matrix formulation

gel ointment matrix shows good viscosity viscidity and lower membrane residues

smooth appearance

conformed to medicinal standard.