Objective: To study protection on myocardium and mechanism of Kangdu Buxin Capsule on model rats with acute myocardial ischemia. Method: Seventy two Wistar rats were randomly divided into sham operation group

model group

positive group

Kangdu Buxin Capsule low

medium and high dose groups

each group orally administered 14 days. Then

model rats with acute myocardial ischemia were prepared by coronary artery ligation. The influences on the content of creatine kinase (CK)

lactate dehydrogenase (LDH)

malonaldehyde (MDA)

superoxide dismutase (SOD) were observed. Result: Kangdu Buxin Capsule significantly reduced the content of CK

MDA

LDH in serum of model rats with acute myocardial ischemia. Kangdu Buxin Capsule significantly improved the content of SOD in serum of model rats. Conclusion: Kangdu Buxin Capsule has a protective effect on model rats with acute myocardial ischemia prepared by coronary artery ligation.