Objective :To observe the effects of Danqing soft capsule (DSC) on insulin resistance and leptin resistance in rats with non-alcoholic fatty liver disease (NAFLD). Method :SD rats were randomly divided into control group

model group

DSC high dose group

medium dose group

low dose group

and polyene phosphatidyl choline (PPC) group. rat non-alcoholic fatty liver model was established with high fat diet.DSC high dose group

medium dose group and low dose group were administrated with different concentrations

which are respectively equivalent to petroleum ether extract of salvia 0.456

0.228

0.114 g ·kg-1. PPC group was treated with PPC by 0.159 g ·kg-1ig.Control group and model group were given the same volume (1.2 mL ·kg-1) of distilled water ig. After treatment for 4 weeks

blood glucose was measured; levels of serum insulin and leptin were assayed by ELISA assay; expression of leptin receptor in the liver was observed by immunohistochemical staining; the index of insulin resistance was calculated. Result : Concentrations of FGB

FINS and HOMA-IR in control group

TCM groups and western medicine group were significantly lower than those of model group (P<0.01

P<0.05); the levels of leptin in serum and expression of ob-R protein in liver of control group

TCM groups and western medicine group were significantly lower than those of model group (P<0.01

P<0.05). Conclusion :DSC can improve IR and leptin resistance in rats with NAFLD.