Objective: To optimize extraction process of Kun'an granules. Method: Arranged experiments with uniform design method

investigated main factors of solvent dosage

extracting time and extracting times

extract percentage and extraction rate of paeoniflorin were as index

multi-index comprehensive score was used to optimum water extraction process; investigated main factors of ethanol concentration

extracting times

ethanol volume and extracting time

extract percentage and extraction rate of total flavonoids were as index

multi-index comprehensive score was used to optimum water extraction process. Result: Optimum water extraction conditions were: extracted 2 times with 12 times the amount of water for 1.5 h each time;optimum ethanol extraction conditions were: added 9.6 times the amount of 30% ethanol

extracted 3 times for 2 h each time. Conclusion: The optimized extraction process was reasonable

stable and feasible.