Objective: To observe the alleviating effects of Jingfang Baidu San on acute alcoholism in mouse. Method: The mice were randomly divided into five groups

including normal

group

model group

Jingfang Baidu San high

moderate

low-dose group( the dose was calculated by the amount of crude drug 32.4

16.2

8.1 g·kg-1

and ig given before or after 30 minutes of drinking alcohol).Except normal group

the model of acute alcoholism was established by drinking 14 mL·kg-1 56° Hongxing Erguotou alcohol once. The rate and time of alcohol drink were observed after preventing treatment

and the death rate and sober-up time were observed after treatmen. Alcohol density in serum and the activity of 14 mL·kg-1(ADH) in liver and stomach tissue were observed. Result: Compared with model group

the rate of alcohol drink in Jingfang Baidu San group was decreased (P<0.05)

and the time of alcohol drink was longer(P<0.01). The death rate in Jingfang Baidu San group was decreased(P<0.05 orP<0.01)

and sober-up time was shorter (P<0.05 orP<0.01) after treatment.Compared with normal group.The alcohol density in serum was increased and the activity of ADH in liver and stomach tissuedecreased in model group (P<0.01). Compared with model group

the alcohol density in serum of each group were decreased(P<0.01)

the activity of ADH in liver and stomach tissue in Jingfang Baidu San group were increased(P<0.05 orP<0.01).Conclusion Jingfang Baidu San can improve the activity of ADH in liver and stomach tissue in acute mouse alcoholism

and promoting alcohol metabolism to reduce alcohol density

so Jingfang Baidu San can alleviate acute alcoholism in mise effectively.