Objective :To develop efficient and rapid of paeonol self-emulsifying drug delivery system

improve onset time and bioavailability. Method :Selected appropriate oil phase

emulsifier

cosurfactants

drew pseudoternary phase diagram on this basis.Determined optimum formulation and prepared tablets by screening proportion of formulations

combining drug loading of prescription and stability of microemulsion.Investigated size

shape and in vitro dissolution condition of emulsified microemulsion. Result :Optimum prescription was as follows:octyl decyl acid triglycerate

cremophor EL and propylene glycol were screened as oil phase

emulsifier and co-emulsifier respectively.The percentage of paeonol was 30% in co-emulsifier. Dissolution of self-emulsifying tablets reached 80% in 20 min. Conclusion :Advantages of developed self-emulsifying tablets were small size

high drug loading

stable

and could significantly improve in vitro dissolution.