Objective: To investigate the clinical effect of Bushen Huoxue Decoction on chronic aplastic anemia (CAA) patients

and observe the effect on expression level of myelo-cytokine C-met SF. Method: Sixty CAA cases were randomly divided into treatment group and control group. Treatment group: the patients were given Bushen Huoxue Decoction

and one dose divided into 2 times daily. Control group: the patients were given Zaizhang Shengxue tablet and each took 5 pills 3 times daily. The course of treatment was three months. This experiment employed reverse transcription- polymerase chain reaction (RT-PCR) method to exam the change of expression level of bone marrow mononuclear cell (BMMC) C-met SF receptor mRNA. Result: The expression level of BMMC C-met SF receptor mRNA in CAA patients was higher than that in normal control group. And in both treatment groups the expression levels were descended in different degree. Moreover

the descent in Bushen Huoxue Decoction group was superior to that in Zaizhang Shengxue tablet group. Conclusion: There was abnormal expression of bone marrow SCF receptor C-met SF in CAA patients; Bushen Huoxue Decoction can improve the hematopoietic function of bone marrow to promote restoration by regulating the bone marrow C-met SF mRNA.