Objective : To prepare silybin gelatin microsphere

and evaluate its in vitro release performance. Method : Silybin gelatin microsphere were prepared by emulsion chemical cross-linking method.Based on result of single-factor test

preparation technology was optimized by orthogonal test.And studies on particle size

shape

in vitro release characteristics and preliminary stability. Result : The microsphere were round and smooth.Average particle size was(1.45±0.27)μm

drug loading rate was(56.24±3.17)% and average entrapment was(79.54±5.07)%.Drug release in vitro profile could be described by Higuchi equation Q = 15.627 5t1/2-1.502 8 ( r = 0.998 5).The microsphere was stable at room temperature for 3 months. Conclusion :In this study

silybin gelatin microsphere was preliminary stable

its in vitro release characteristics conformed with characteristics of sustained-release formulations.