Objective : To investigate bleeding risk induced by Danshen injection

and to provide safety data for clinical treatment. Method : Chinese biological medical disc (CBM) was searched by the formulae of ‘Salvia miltiorrhiza injection’ or ‘injection powder’ and ‘side effects’ or ‘adverse events’ or ‘bleeding’ or ‘blood clotting’ or ‘coagulation’

with duration from 1979.01-2009.08 for the literatures with Danshen injection adverse reaction case report. Result: ① A number of 1659 documents is retrieved and 86 medical reports are selected. Among them

86 cases in the literature reported 7 900 cases of adverse reactions

involving 395 cases of Danshen injection cases (0.05%). The primary diseases of adverse reaction cases are mainly cardiovascular disease and cerebrovascular disease (58.1%). ②Adverse events include bleeding 16 records (18.6%)

rash 14 records (16.3%) and shock and death each 7 records (8.1%). Conclusion : The reports indicates that the ratio of adverse events and bleeding events induced by Danshen injection is low.