Objective: To explore the effects of ultra-powder Liuwei Dihuang on recognition and basic fibroblast grouth factor(bFGF) in Alzheimers disease rats

and the mechanism of ultra-powder Liuwei Dihuang promoting recognition. Methold: The rat model of Alzheimer was established by Injection of Aβ1-40

rats were randomly divided into normal group

sham group

model group

Chinese medicines group

then at 5 d and 30 d rats were executed to evaluate the recognizing function

bFGF was assayed by ELISA and RT-PCR. Result: After modeling

rat escape latency was significantly longer

there was significant difference between the model group and Liuwei Dihuang group at 30 day (P<0.05); there was not significant differences between sham-operated group and Liuwei Dihuang group.In the normal and sham-operated group rat brain had a low level bFGF

it was increased in model group and the Chinese medicines group at 30 day

there was significant difference between the model group and Liuwei Dihuang group at 30 day point (P<0.05); there was not significant differences between sham-operated group and Liuwei Dihuang group. Conclusion: Rat recognition was declined after injection of Aβ1-40 intracerebral

ultra-power Liuweidihuang can promote recognitive function

can enhance bFGF expression in AD rat

which may be possible mechanism of yizhijiannao.