Objective: To investigate the effects of Kaixin Jieyu decoction on the concentraion changes of norepinephrine (NE)

dopamine(DA) and serotomin(5-HT) in brain of depression model in rats. Method: Thirty male SD rats were evenly randomized into normal

model and medical groups. Depression model of rat was produced by using chronic unpredictable mild stress stimulation (forced ice-water swimming

electric shock

tail-clamping

etc) combined with lonely raising for 21 days.At the same time of producing the depression model

Kaixin Jieyu decoction (40 g ·kg-1) was given to the medical group rats

once daily

continuously for 21 days.The concentraions of NE

DA and 5-HT were detected by HPLC-ECD. Result: The concentraions of NE

DA and 5-HT were reduced significantly in brain of the model rats compared to that of the normal group(P<0.05);also the concentraions of NE

DA and 5-HT were increased significantly in brain of Kaixin Jieyu decoction group compared to that of the model group (P<0.05). Conclusion: The mechanism for anti-depression of Kaixin Jieyu decoction may be correlative to regulating the balance of monamine transmitter.