Objective :To investigate the protective effects of compatibility of dioscin and borneol on the focal cerebral ischemia in rats. Method :Rats were randomly divided into control group

model control group

groups with prescription 1-6 of compatibility of diosgenin and borneol

compatibility of diosgenin and borneol was based on the method of increase-decrease design method of experiment with baseline geometric proportion. Rats were given medicine of 10 mL·kg-1intragastrically

once a day

lasting 7 days

after 1 h of the last administration

focal cerebral ischemia model was established in rats of the middle cerebral artery

determining neurological behavior score after the rats were awake immediately

TTC staining was used to determine method infarction area and brain water content after 24 h of model . Result :Compared with model group

rescription 2

3 could alleviate neurological score

decrease infarct size

brain water content(P< 0.05

P< 0.01)

prescription 1 can reduce neurological score

infarct size and brain water content(P< 0.05)

prescription 4

5

6 have no significant differences. Conclusion :The best ratio of dioscin and borneol are 8 ∶2 and 6 ∶4 in terms of protection on focal cerebral ischemia in rats.