Objective: To study the effect of Shengbao granula on immunological function in mice with immunological deficiency. Method: Carbon clearance test

T lymphocyte esterase conversion rate test

2

4-dinitrofluorobenzene-induced delayed type hypersensitivity test(DTH)

and hemolysin antibody formation induced by chick erythrocyte were employed to evaluate the effectsa of shengbao granula on immunological function. Result: Shengbao granula(7.50

3.75 g·kg-1)group could increase the K value and the weight index of spleen in d14 after administration (7.50

3.75 g·kg-1)group increased peripheral T lymphocyte proliferation in d7

enhanced murine ear swelling in d13

and could not increased hemolysin antibody in d10. Conclusion: Shengbao granula significantly improves nonspecific and cellular immunity function in mice with immunological deficiency.