Objective: to observe protection of total flavonoids in anti-coxsackie B complex capsule(K-CoxB-JN) against acute myocardial injury caused by adriamycin in mice and to discuss the feasible mechanism. Method: One hundred and seventy five Kunming mice were selected and diveded into 7 groups

including high dose group of flavonoid (0.8 g·kg-1)

middle dose group of flavonoid(0.4 g·kg-1)

low dose group of flavonoid

model group(0.2 g·kg-1)

Xinxuekang group

blank group and original formula group.

there 25 mice in each group are taken. After a week

model of acute myocardial injury was established by adriamycin injection of 20 mg·kg-1. Blood was collected after 24 h of model building

then determination of myocardial enzyme like SOD and MDA were performed as well as indexes of heart and spleen. Result: Activity of myocardial enzymes was decreased drastically with total flavonoids in K-CoxB-JN

as well as indexes of heart and spleen

especially middle dose group of flavonoid. Conlusion: Total flavonoids in K-CoxB-JN do prectect mice against acute myocardial injury. The possible meachanism may be related to antioxidation and scavenging of oxygen free radicals.