Objective: To optimize the extraction process of flavone in Phyllanthus urinaria based on celluase

and provide the basis for the efficient use of P. urinaria. Method: The single factor test was performed to study the effects of the material-liquid ratio

extraction temperature

extraction time and the concentration of cellulase on the yield rate of flavone from P.urinaria. The process of extracting flavone based on cellulose was optimized with orthogonal test. Result: The results showed that the optimized extraction condition of flavone in P.urinaria based on cellulase was as following: the concentration of celluase was 4.25 g·L-1

the extraction temperature was 40 ℃

the material-liquid ratio was 1∶30 and the extraction time was 1.5 h. Under the optimized condition

the extraction ratio of flavone was high of 1.51%. Conclusion: In the present conditions

the extracting efficiency of flavone from P.urinaria based on celluase is better

and it has a promising future in application.