Objective: To provide basis on clinical application of dried earthworm. Method: Drying method including freeze drying

dried in the sun and dried by heat in different temperature were taken. Determined thrombolytic valences as index. Result: The valences of earthworm dried in the sun

dried at 40 ℃

vacuum drying at 40 ℃ and freeze-drying were no difference

but the valence was decreased significantly when temperature was higher than 50 ℃. Conclusion: Drying method of earthworm could be identified as drying in the sun or dried at 40 ℃.