Objective: To observe the clinical curative effect and safety of icterus due to divided into two groups

the treatment group(n=43) treated with the combination chronic cholestasis treated withpurgation dispersion purification harmonization. Method: Eightg-five patients with Icterus due to chronic cholestasis were selected. They were randomly of purgation dispersion purification harmonization and western medicine

the control group(n=42) with western medicine. Result: After four weeks treatment

the treatment group was superior to the control group with regard to total effective rate (90.70% vs 83.33%

P<0.05) and improvement of liver function including TBIL

ALT and γ-GT(P<0.05 or P<0.01). The treatment of purgation dispersion purification harmonization was effective in cleaning up remnant icterus andwithout significant side effects. After three months follow-up

the level of Tbil

ALT and γ-GT did not rebounded. Conclusion : It was effective of Using the combination of purgation dispersion purification harmonization and western medicine to treat icterus due to chronic cholestasis. This therapy could help to clean up remnant icterus and was safe.