Objective: Explore the best compatibility proportion of rhizoma coptidis and Fructus Forsythiae’s anti-inflammatory effect. Method: Research the effect of each proportion of rhizoma coptidis and Fructus Forsythiae to the swelling of rat’s toe caused by injecting egg albumin. Give each groups berberine

forsythia

the ratio of the drug

aspirin

and saline.Respectively

5

30 min

1

2

4

6 h measure toe volume

calculate swelling rate. Establish an HPLC method for simultaneous determination of indicator ingredient of each proportion. Looking for links between them. Result: Berberine

forsythia proportion of the compatibility have an effect on inhibition of swelling. By analyzing the compatibility proportion of rhizoma coptidis and fructus forsythiae’s is 1 ∶1

it has the lowest swelling rate

therefore

has the most effective anti-inflammatory. There is the highest composite score when the compatibility proportion of rhizoma coptidis and fructus forsythiae’s is 1 ∶1. Conclusion: The best compatibility proportion of rhizoma coptidis and fructus forsythiae’s anti-inflammatory effect is 1 ∶1.