Objective: To study clinical efficacy of Qishen Qinggan Decoction combined with lamivadine for treatment of chronic hepatitis B(CHB). Method :Seventy-nine CHB patients were randomly divided into two groups

41 were involved in treatment group

38 were involved in control group.The treatment group were treated by Qishen Qinggan Decoction combined with Lamivadine

the control group was treated by lamivadine.Fifty-two weeks for a course of treatment.Serum level of HBV DNA

HBV-M

liver function were detected to compare the therapeutic effect. Result :Baseline characteristics were well balanced between two groups. The serum HBV DNA became undetectable(<1 000 copies/mL)in 92.68% of treatment group vs 76.31% of control group(P<0.05).The rates of serum HBeAg became negative between 2 groups

were 46.67% vs 20.69%(P<0.05). The rates of serum HBeAg seroconversion between 2 groups were 33.33% vs 17.24%. The rates of hepatitis B virus variation between 2 groups were 4.88% vs 10.52 %. Liver function(ALT

AST

TBil

ALb)was significantly improved in both groups(P<0.05

P<0.01). Conclusion :Qishen Qinggan Decoction combined with Lamivadine for the treatment of CHB has better virus responsion.