Objective: To explore the optimun technique parameters on preparing clinopodii saponin microspheres by spray drying technique. Method: HPLC were used to determine the content of clinopodii saponin A

Investigate the influence factors with appearance

the loading capacity and entrapment efficiency as indexes

such as inlet temperature

feeding rate

kinds of plasticizer

ratio of drug to coating material. Result: The optimum technique parameters was as follows: inlet temperature at 90 ℃

feeding rate as 2.5 mL ·min-1

kinds of plasticizer was glycerine

ratio of drug to coating material was 1 ∶4. Conclusion: Clinopodii saponin microspheres accorded with expected demand.The optimum technique was reasonable

feasible.