Objective: To optimize purification technical conditions and parameters of Dange dropping pills by macroporous resin. Method: Investigated adsorption property and elution parameters of macroporous resins by using the content of salvianolic acid B and puerarin as indexes. Result: Finally

purification technology was determined as follows:AB-8 was optimal resin type.Capacity of AB-8 macroporous adsorptive resin was as much as 2 times to sample load(φ ∶h=1 ∶6)

flow rate of sample was 1 BV·h-1

5 BV amount of distilled hydrochloric acid solution(pH 4)used for eluting

and 3 BV amount of 50% ethanol as desorption solvent. Conclusion: Optimum refining process of Dange dropping pills by macroporous adsorption resin was simple and feasible with good effect of separation.It could decrease the yield of extract

and dose of drug was decreased.