Objective: To establish a sensitive HPLC-ELSD fingerprint method for controlling the quality of Compound Tangmaikang. Method: HPLC analysis was performed on a Welch Material Cl8 column (4.6 mm×250 mm

5 μm) with a mixture of acetonitrile and water as mobile phase in gradient mode. The drift tube temperature was at 55 ℃

gas flow was 1.8 L·min-1

gain value was 1

and column temperature was at 40 ℃. Result: Twenty-four peaks were identified in the HPLC fingerprint of Tangmaikang and their similarities were more than 0.80. Good precision

stability and repetition were showed. Conclusion: This method provides evidence to quality evaluation of Tangmaikang.