Objective: To study the distribution and metabolism of bismuth in Weishu San in rat blood

providing the basis for further clinical studies. Method: Blood sample was collected at 5

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240 min after feeding healthy rats with Weishu San suspension solution. The bismuth content detected by inductively coupled plasma mass spectrometry (ICP-MS). Result: Measured data show that plasma concentrations of bismuth reached a peak at 0.5 h

peak concentration of 15 μg·L-1 or so

and then decreased rapidly

down to a lower level at 7 h. The absorption half-life of bismuth in rats was 14.691 min and elimination half-life was 293.422 min. The total body clearance of bismuth in rats achieve 1 571.044 L·min-1·kg-1. AUC was 2 063. 515 μg·L-1·min-1. Conclusion: Pharmacokinetic model of bismuth in rat meets two-compartment model with first absorption.